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Showing posts with label Stress. Show all posts
Showing posts with label Stress. Show all posts

Sunday, January 28, 2018

Wearable IoT Neuroflow for treating the PTSD patients. 01-29


A Veteran Entrepreneur


If you can lead soldiers into battle, you can cold call 140 investors.


Neuroflow founder Chris Molaro, WG’17, is a veteran, and he’s seen the effects of PTSD. As he reminds us, “20 veterans a day commit suicide, on average.”
Neuroflow is his way of fighting back. Neuroflow uses wearables to measure the physical effects of stress, and quantify them in a way that is useful to therapists who are treating people for severe anxiety and stress. For the first time, therapists can use quantifiable measurements to see if their therapies are working—and adjust for maximum effectiveness.
The Importance of Persistence

Neuroflow is also a story of persistence. Chris started working with his cofounder, Adam Pardes, who is an engineering PhD candidate at Penn, on a project for the Y-Prize, which asks students to commercialize Penn technologies. In Chris’s words, they “lost miserably.” But the idea was what set them on the path to Neuroflow.

They won the Innovation Prize in the Penn Wharton Startup Challenge, and got a lot of other support from across the University. Chris says that, “before raising the investment capital we won a total of $140,000 in business plan competitions, thanks in large part to Wharton.”
But when they set out to raise serious money, it took time, and a lot of persistence. They ultimately raised $1.25 million. Doing so took them months of conversations, and talks with 140 investors. This, as Karl points out, isn’t especially uncommon—so for you entrepreneurs out there who are looking to raise funds, get ready to start calling.
Our Own Battle

For Chris, he sees Neuroflow as “our own war zone, our own battle, and we have to figure out a way. And we’ve got great men and women to our left and right in the office, and we’ll figure it out.”

What is Neuroflow, 


Originally appeared in The Philadelphia Inquirer, written by Anna Orso.


When Clark Griswold tried to blanket his home in Christmas lights, an electrical glitch rendered the facade completely dark. But it was his gruff in-laws who added insult to injury. “Beautiful, Clark,” said one. The other called it a “silly waste of resources.”


This is a scene from the 1989 classic National Lampoon’s Christmas Vacation. But you don’t need to summon Chevy Chase to feel some sort of way at the mere mention of your in-laws.


Finances, gift-giving and, yes, difficult family members all contribute to higher levels of stress during the holiday season. Now, thanks to a Philadelphia startup, there’s an app for that.


A Wharton grad and a Penn Ph.D. student last year founded NeuroFlow, a startup that’s developed software to interpret brain waves and heart rate to measure relaxation and help patients and clinicians visualize how external stressors trigger physical reactions.


The software shows that even the mention of one’s in-laws can set off in some people a physiological response – that gut-level feeling of uneasiness – and can then illustrate exactly how meditation and mindfulness techniques impact the body and brain. But the tool, now in beta and used by a handful of mental health professionals, has applications far beyond the holiday season. Its founders are planning a full launch in February, and believe their platform will ultimately help de-stigmatize mental illness by helping people see it, rather than just feel it.


A lofty goal for a company with eight full-time employees run by a couple of twentysomethings.


“We know it’s a stressful time of year, yet what we found is that the conversation around mental health, around anxiety, around stress is such that there’s this negative stigma,” said CEO and co-founder Christopher Molaro, 29, an Iraq war veteran and Wharton MBA who founded the company in large part to address post-traumatic stress disorder. “I think it’s because if you can’t understand something, measure something, see something, you just push it aside as something that doesn’t exist.”


NeuroFlow is a phone app and cloud-based program that, through bluetooth technology, interprets data to offer digestible information about how relaxed a person is. That data comes from a heart-rate monitor and an EEG (electroencephalogram), in this case a headset, which measures electrical activity in the brain.


The idea is that clinicians would be able to visualize exactly when a patient becomes more stressed, and can then watch in real-time as relaxation techniques like breath monitoring start to actually work. That visualization helps people see mental illness in the same way they can see a broken arm on an X-ray.
Sound complicated? I tried it out this week in a conference room at Benjamin’s Desk, the Center City coworking space where NeuroFlow is based.


Adam Pardes, the company’s 26-year-old co-founder and chief operating officer, helped me put on a headset (similar to the one in the photo above) that retails for about $250. The NeuroFlow program recognized I was wearing the headset, and the line that charted my score on the “relaxation index” was sky high.


Safe to say this reporter is not very relaxed. NeuroFlow confirmed it.


But with the help of a breathing guide that acts a bit like a metronome, I watched the line go down. After just about a minute, I’d gotten into the “relaxation zone,” and I was able to see it.

Other variances in anxiety and stress can be seen with NeuroFlow’s YouTube integration, a tool that allows therapists to show a patient a video – say it’s of a car driving over a bridge for a person who fears that – to see the exact point when a patient’s body goes into anxiety mode.


Using the technology, a patient would also be able to gauge progress with a therapist over time. The tool isn’t meant to replace a mental health professional, though. Think of NeuroFlow more as a thermometer for mental health.


“Your body physiologically changes when you’re more stressed and more relaxed,” Molaro said. “The fact that we can measure and better understand means that you don’t have to be ashamed of it and can go seek help, whether using our platform or not.”


Molaro said NeuroFlow closed its first major funding round in October, raising $1.25 million in venture capital. It’s also supported in part by Penn, where the company is conducting some research through the school’s Neuroscience Initiative.


Sixteen clinicians across the country are currently using NeuroFlow in beta, and the full software will be available for purchase online for about $100 per month.


Molaro and Pardes, who has a background in bioengineering, see a host of applications for clinicians and patients down the line, from testing stress levels in soldiers to tracking mental health in professional athletes to managing that Griswold-level holiday stress.


“Twenty veterans a day killing themselves is unacceptable. Fourteen students at Penn killing themselves is unacceptable,” Molaro said. “My mom crying on Christmas because she’s anxious and stressed out is unacceptable. People deserve better.”


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Sunday, December 31, 2017

All you need to know about agitated depression 01-2018



Depression is a persistent state of feeling hopeless, sad, or helpless. While there are some common symptoms associated with depression, people can experience depression differently.




One such example is agitated depression. Medical experts may also describe agitated depression as anxious depression or distraught depression.

Though agitated depression is not a distinct type of depression, psychiatric professionals recognize that some people have symptoms of depression as well as agitation.

Fast facts on agitated depression:

Psychiatrists do not define agitated depression as a distinct type of depression.

Agitation can be a common symptom of mood disorders.

Doctors call depression with agitation a "mixed episode" of depression.

Symptoms

Depression with agitation, is known as a "mixed episode" of depression.

Mental health professionals use a manual called the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) to diagnose mental health disorders, including depression.

By using the same criteria, doctors across America can diagnose depressive symptoms in the same way.

For a doctor to diagnose someone with depression, the person must have experienced depressed mood or a loss of interest or pleasure in life (anhedonia) for at least 2 weeks.

Also, a person will also have experienced at least five of the following symptoms:

Feelings of sadness, hopelessness, or irritability on a nearly daily basis.

Lack of interest or pleasure in activities almost every day.

Experiencing significant weight loss or appetite loss that results in weight loss.
Difficulty sleeping or sleeping excessively.

Experiencing psychomotor agitation, restlessness, or feelings of being "slowed down."

Feeling fatigued or having a lack of energy nearly every day.

Feeling worthless or having excessive and unexplained guilt almost every day.

Difficulty thinking clearly, concentrating, or making decisions on a daily basis.

Experiencing thoughts of death, thinking of harming one's self, or creating a specific plan for committing suicide.

Agitation is a symptom that can cause a person to experience feelings of uneasiness and anxiety.

Some of the symptoms associated with agitation include:

angry outbursts

clenching fists

disruptive behavior

excessive talking

feeling as if a person cannot sit still or focus
pacing or shuffling feet

tension

wringing of the hands

violent outbursts

A person who has agitated depression experiences feelings of helplessness that can make them feel out of control.

As a result, they can then feel hopeless, which may lead to depressive thoughts. Agitation can cause a person with depression to act impulsively. This could cause a person to hurt themselves or others and engage in harmful behavior.

Depression has many different methods of treatment including self-help. Learn more about the best depression blogs to manage low mood here.

A person with bipolar disorder may experience fluctuating symptoms of depression and mania (an elevated state of being).

Mania is different from agitation because mania causes a person to feel hyper, "high," or overly energetic. A person may only sleep a couple of hours each night and stay awake for extended periods.
Mania does not feel good or euphoric to every person, but it can to some people.

Causes

Depression may be caused by a significant life event, such as the loss of a family member.
Agitation is often a symptom of an underlying mood disorder and is not a condition of its own. The causes of depression itself can be varied and can occur if:

the brain does not regulate mood appropriately

a person has a family history of depression and is more vulnerable to the condition

a person has experienced significant life events that are especially stressful or sad, such as the loss of a family member or divorce

a person has several chronic medical problems

Several of these factors can contribute to depression. However, doctors do not know why a person may experience agitated depression.

A person's temperament that affects their behavior may increase the likelihood that they will experience agitation related to depression.

How is it diagnosed?

Doctors diagnose agitated depression by asking a person to describe the symptoms they are experiencing.

They may ask questions, such as when the symptoms first began, what makes the symptoms better, or what makes the symptoms worse. Sometimes a person's loved ones may also describe the changes they have observed in a person's personality.

A doctor will use the criteria from the DSM-5 to diagnose a person with major depressive disorder, but agitated depression is not diagnosed using DSM-5 criteria. A doctor will also try to rule out other similar conditions, including bipolar disorder.

How is agitated depression treated?

A psychiatrist or other mental health professional may help to treat agitated depression.

Doctors treat agitated depression with a variety of approaches.

In the first instance, a doctor may prescribe medications called sedatives or benzodiazepines.

Examples may include diazepam (Xanax) or lorazepam (Ativan). These medications work quickly to help a person feel calmer and can temporarily relieve agitation.

Additional steps include:

Medications to relieve depression: Doctors may prescribe a variety of drugs to relieve depression, including anti-depressants. If a person does not respond to these medicines, a doctor may add another drug or prescribe a different medication type entirely. Examples can include anti-anxiety medications or mood stabilizers.

Counseling: Seeing a psychiatrist or other mental health professional can help a person identify thoughts and feelings that can signal the start of agitation or depressive symptoms. Therapy can help a person focus on thoughts and behaviors that can help them feel better when they struggle with agitated depression.

Stress-relieving techniques: Relieving stress and depression through physical activity, meditation, deep breathing, and journaling can all help a person cope with feelings agitated depression.
There is no one single solution to treating agitated depression. A doctor must consider a person's unique symptoms.

They will likely take a variety of approaches, including prescribing medications and recommending therapy.

Sometimes it can take several months or even years for a person to find the right combination of medications, therapy, and stress-relieving techniques that help them live better with their agitated depression.

Takeaway

While there is no cure for agitated depression, there are many treatments that can help a person live a healthier, happier life. Although finding the right combination of treatments can take time, help is available.

If a person experiences suicidal thoughts or thoughts of self-harm, they should seek emergency medical attention. Medical professionals can help identify ways to stabilize the person medically, and reduce the risks of them injuring themselves. 

Thursday, October 12, 2017

What Ants Mice Monkeys can teach us about the impact of stress 10-13













Stress is a common feeling, and it seems we’re dealing with more of it in our lives than ever before. Work, finances, relationships — all have the ability to create chronic stress that can lead to anxiety, depression and other issues. Two Penn Integrates Knowledge (PIK) professors — Michael Platt, a Wharton marketing professor and professor of neuroscience and psychology at Penn, and Shelley Berger, a Penn professor of cell and development biology and director of The Epigenetics Institute, have teamed up in an interdisciplinary approach to learn more about how stress affects individuals.

Platt and Berger recently spoke about their research and its implications on the Knowledge@Wharton show on SiriusXM channel 111. 



Following is an edited transcript of the conversation. 

Knowledge@Wharton: Tell us the background behind this research.

Shelley Berger: It’s something we’ve been interested in for some time. The research I’ve been doing is focused on epigenetics, which has led into this interest in the environment and how it affects behavior. But in recent years, we’ve become very interested in the brain from work we started on the ant system. We actually have an ant lab at the Perelman School of Medicine. We’ve been interested in ants and studying their behavior. They’ve been a great model for behavior. Recently, we became interested in mouse behavior and studying the brain and epigenetics in the brain. Through conversations with Michael, that led to how this whole thing began on crossing species and studying mouse, primate and even human.

Knowledge@Wharton: Give us a better understanding of epigenetics.

Berger: Epigenetics is the study of how the environment affects the way genes are expressed. We commonly think about mutations affecting genes and gene expression. But epigenetics is the study of how the environment can affect the way genes are turned on and off without mutation. Specifically, it’s the effect of how chemicals coming in from the environment through our bodies can sort of decorate the proteins that associate with the DNA and change the way genes are turned on and off. That’s of great interest because many things are coming in from the environment, including stress. We’re talking about psychological effects and stress, and that can lead to changes in the brain. Post-traumatic stress disorder is a great example.
“Burnout is the number-one topic that I hear about from our MBA students, and they want to do how to deal with that…. Stress is everywhere.” –Michael Platt
Knowledge@Wharton: Michael, tell us about your interest in this research?

Michael Platt: We have been interested in behavior for a long time. We got interested in how genes affect the development of the structure and function of the brain and nervous system to ultimately produce behavior. Of course, that equation leaves out the central role of epigenetics that Shelley just described, which is that the same genes in the same body in a different environment can lead to very different outcomes. If you imagine yourself living with lots of family support, for example, you might respond better to the stresses of the environment — to a stock market crash, to problems in the economy, etc. But if you are living alone without any social support, then that stressful event or the long-term stress can be much more impactful on your body and your brain.

Shelley and I met two years ago, when I had just arrived here from Duke University…. As we were talking, we began to realize that we were interested in very similar things, although our expertise is very complementary. We had been working on the neurophysiology of behavior, the neurophysiology of social behavior and how genetics might influence that. But we had really no expertise in epigenetics at all.

Knowledge@Wharton: How will this research lead to a better understanding of the human brain and how it reacts to stress from environmental factors?

Berger: We’ve been studying mouse behavior for the past five years, and you can model stress in mice. There’s a method called “fear conditioning” by which you subject the mouse to stress, and then you can study what happens to the brain. How are learning and memory affected by the stress of fear conditioning?

We had been working with post-mortem human brains from people who had suffered neuro-degeneration from Alzheimer’s Disease, so we’d been developing a lot of methodology to study parts of the brain. Humans are difficult because, of course, they’re not experimental animals. We have to work out all the methods to carry out high-resolution studies of these chemical marks in the brain from human post-mortem samples. Then, starting to get interested in some results we had in mouse, we thought that the crossover between fear conditioning in mouse and PTSD in human could be really interesting. We got in touch with a guy who has a bio-bank of humans who had suffered from PTSD. We can take these methods that we’ve developed in mouse, then fine-tuned in human post-mortem brains through our work on Alzheimer’s, and now we can look at PTSD in humans. Michael filled in the middle part with primate research, which is a great link between the two.

Platt: Right. As useful as a mouse is for understanding a lot of the basic processes that we think are involved in the response of the human brain to stress, sometimes that translation is not perfect. That reflects the fact that mice and humans last shared a common ancestor much longer ago than humans and monkeys. For that reason, the human brain and the monkey brain are much more similar than the human brain and the mouse brain. There are certain aspects of behavior, in terms of behavioral complexity and social complexity, that are shared between humans and monkeys, that are less well-paralleled in the mouse.

The monkey gives us the capability to look at some of these other issues like social support and how that might help with the problems that one encounters with social competition. This is very different from what mice experience. People and monkeys live in groups for a good reason. It allows you to do things that you can’t do alone, like evade predators or chase away other groups and get resources. On the other hand, when you’re living in a group, you have to compete with everybody else. That’s a source of stress that I think we all can easily identify with.

This is a beautiful partnership because it has the potential to lead to understandings that can lead to new treasuries. Also, putting my Wharton hat on, this kind of project can potentially illuminate ways in which we might be able to mitigate stress, say, within the workplace. That’s a huge problem these days. Burnout is the number-one topic that I hear about from our MBA students, and they want to do how to deal with that. You hear the same thing from residents who are training in medicine. Stress is everywhere.

Berger: The beautiful thing about the primates, with respect to humans, is that humans are not an experimental animal — we don’t know exactly what their social situation is in its entirety. But scientists watch [primates] all the time. Michael has scientists working with him, watching these animals in their natural habitat, so they know exactly what sort of place they have in the social spectrum. We can’t know all that about humans. As much as we get metadata about humans — that we can get information about their background — they’re not experimental animals. We can’t control and know.
“We’re not talking about the kinds of stresses our kids go through over smartphones. We’re talking about the kinds of things that really impede your ability to function.” –Shelley Berger
Knowledge@Wharton: That space between mouse and monkey feels like it’s very important because there’s more of a more recent link between monkey and human than human and mouse.

Platt: I think that’s why these studies need to be done. There are very few places where you can really do them and where people will collaborate to try to discover those links and make the connections. I think what Shelley can do in her lab, with really exquisite techniques and technologies that allow you to hone in on the mechanism, we can closely approximate in primates. But it’s not the same kind of thing that we can do.

On the other hand, what we can provide is a much richer understanding of the social environment and all of the other factors that might affect an individual in how they respond to stress and how that ultimately leads to changes in behavior. The particular population of monkeys that we study evolves. This is a population in which individuals are free to fight and to flee and to breed. Some monkeys do better than others. That means that whatever traits those individuals have — traits that allow them to offer stress, to make alliances and connections — can be passed on to the next generation. We can see these kinds of changes in the population over time. That’s almost impossible to see in people.

Knowledge@Wharton: If you find enough links, you’re talking about being able to deal with a lot of prevalent medical issues — burnout, depression, suicide, PTSD.

Platt: It’s really compelling to see the data. There has been a lot of attention paid to a new report that analyzed the incredible increase in depression and anxiety, especially in teenagers, after the introduction of smartphones in the 2000s. There does seem to be, potentially, some link to the kinds of technological environments in which we find ourselves. I think one implication is that it leads to social disconnection, which I think reinforces what we’ve learned both in people and in monkeys that having social support is really critical. If you don’t have it, then things really fall apart.

Knowledge@Wharton: The social support is not as much of a factor when you’re talking about mice. But perhaps it is for ants because of how they live in colonies, correct?

Berger: That’s an astute observation. Ants are a great model for complex social interactions, and there are very few models like that. That’s why the medical school supports us to have an ant lab. They see the great translational aspects of studying ants and their social interactions.

Knowledge@Wharton: How do you think that information could play out when you’re talking about dealing with stress?

Berger: I’ll go back to our mouse research, which we’re translating both ways to the ants and would love to translate it to the monkeys and definitely to humans. We discovered that the machinery to make one of the chemicals that’s placed on the genes to regulate them is associated with the genes. It’s an enzyme that makes this chemical, and that enzyme can be inhibited. We think if we inhibit that enzyme, we can alter learning and memory in mouse. This is the kind of experiment you can do in mouse. We can’t do it in primates because they’re too complicated.

One of the things we’ve been talking about is whether an inhibitor like that could be relevant to humans. We’re not talking about the kinds of stresses our kids go through over smartphones. We’re talking about the kinds of things that really impede your ability to function.

Knowledge@Wharton: Going back to the business aspect, if these discoveries lead to treatments down the road, that could chip away at some pieces of the health care problem in this county.
Platt: Sure, and hopefully down the road is not so far down the road. The enzyme that Shelley’s talked about, it’s quite clear that one could imagine developing a drug to target that specific mechanism. If you had a combat veteran who was exposed to a blast or something else incredibly stressful, you could potentially deliver that drug at the right place and the right time and block the formation of bad memories. That would be an incredible opportunity.
“If you had a combat veteran who was exposed to a blast or something else incredibly stressful, you could potentially deliver [a] drug at the right place and the right time and block the formation of bad memories.” –Michael Platt
The other extension of this are ways of trying to mitigate stress before it leads to something. We’re talking about chronic stress rather than acute stress. Are there ways that we can prevent it? There are a lot of options that people are exploring, such as improving your social connections, mindfulness and meditation, exercise. We know those things are all really good. We just don’t know how they work.

Knowledge@Wharton: Is there a difference between people who handle stress really well and those who don’t?

Platt: This is a really tricky and interesting and important question. Is it something you’re born with or something you can teach? There is fabulous work from Penn professor Angela Duckworth on grit, which is this resilience. It seems like some people have a great reservoir of grit, while it’s harder for others to demonstrate it. That leads to the question of whether you can develop it. Can you train it? Can you educate people to display that grit more often? If so, then that’s another approach to dealing with life stress.

Berger: It seems to me that the monkeys are the place to study that because Michael’s group sees which monkeys are accepted.

Platt: One thing that’s really fascinating about the monkeys that we study is that they have personalities, just like people do. The big five personality instruments that you would apply to a person, you could do the same with a monkey. We’ve done that, and their personalities are consistent over time. A monkey who’s very timid and anxious when he’s 6 months old is going to be similarly timid and anxious when he’s an adolescent. A monkey who is very bold or very aggressive, you’ll see those patterns continue. It’s not 100%. It’s not like it’s genetically determined. I think that’s where the fascinating thing is. Maybe 25% or 50% is purely genetic, and the rest is environment in how they respond to it. That’s why this is so important.

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Friday, December 9, 2016

How the Pursuit of Happiness Has Made Us Nervous Wrecks 12-10





Worry, anxiety and nervousness are at an all-time high in American society. The economy, terrorism, politics, work, parenting — the list of stressors is endless. But author Ruth Whippman believes there’s another reason why anxiety has become the new normal for Americans, and it has to do with the notion that happiness must be pursued above all else. The concept is even baked into the Declaration of Independence.

Whippman recently joined the Knowledge@Wharton show on Wharton Business Radio on SiriusXM channel 111 to discuss her new book, America the Anxious: How Our Pursuit of Happiness Is Creating a Nation of Nervous Wrecks.

An edited transcript of the conversation follows.

Knowledge@Wharton: A state of perpetual anxiety does feel like a new norm right now for most Americans.

Ruth Whippman: Absolutely. The World Health Organization says that America is the most anxious country on the planet and by a wide margin. A second-place country is very far down the list from America. We are, in this country, more likely to suffer from clinical symptoms of anxiety than anywhere else on the planet.

Knowledge@Wharton: You’re a British transplant. In doing this book, were you able to gain perspective on what’s going on here that maybe some of us don’t realize?

Whippman: As an outsider, when you come into a place completely new, you perhaps see things in a different way. It was quite the culture shock. We moved here when my husband got a job in Silicon Valley. We moved from fairly gray London to beautiful sun-drenched California. I imagined that my life here was going to be absolutely perfect. Free of anxiety. The beaches. The weather. Everything was going to be wonderful. But I started to notice very quickly that there was this real kind of sense of anxiety here — that far from being in this land of Instagrammed perfection, people were anxious about their lives and not necessarily any happier than the people back in London, who were perhaps a little bit more negative, a bit more cynical.

Knowledge@Wharton: What do you think are the reasons Americans are so anxious right now?
Whippman: There are lots of genuine reasons why life can bring anxiety. Money worries, inequality, the state of the economy, health care — those sorts of big issues. But one of the things that I identified pretty early on was that people seem to be very culturally preoccupied with this idea of happiness, of finding happiness. I was having conversations with people, and the same topic would come up again and again, with people really kind of agonizing about it. Am I happy? Am I as happy as my neighbor? Am I as happy as my friends? Am I as happy as everybody on social media? Could I be happier if I tried harder? There seemed to be this real anxiety about being as happy as you could be.

“Mindfulness starts to feel like a tiny, teeny Band-Aid on a much, much bigger problem.”
I started looking into it, and this is a multibillion-dollar industry in the United States. This industry is devoted to this idea that if we just try a bit harder, if we do another thing, read another book, try another class, then we can become happier. And I think this is one of the big causes of anxiety in American society.

Knowledge@Wharton: Through what avenues is this a multibillion-dollar industry?
Whippman: It’s what you think of as the traditional self-help industry — the books, the apps, the causes. That amounts to about $11 billion. To put it in context, that’s about the same size as Hollywood. Recently, there’s been a new kind of subsidiary industry: for lack of a better term, the quasi-spiritual thing – [including] meditation, mindfulness, yoga. Although these things are supposed to be spiritual practices, they amount to probably the same in terms of the size of the industry.
Sponsored Content:

This is a huge new thing. It’s this idea that if we just buy another app or read another book or try another thing, then this new, improved version of ourselves will be fully self-actualized and fully happy. I think that, itself, is causing anxiety.

Knowledge@Wharton: What is the impact financially, culturally and in other areas?

Whippman: This idea of the American Dream — if you really work hard for something, then you can have it — is just out of reach; we’re trying to get to this kind of happy ever after. Psychologically, that’s pretty tough on people because our emotions don’t work quite like that. Just by trying harder, we can’t actually control our own emotions and make ourselves happier in that way.
It’s having a huge impact culturally. In the book, I start to look at all different areas of life. I look at the workplace, religion, social media, parenting. These ideas about making ourselves as happy as possible have infiltrated all different areas of American life.

Knowledge@Wharton: Focusing on the corporate end, there are people who have a mix of anxiety from both personal life and professional life, which ends up being a toxic formula for them. Think there are people who have anxiety in their personal lives, but work ends up being a catharsis.
Whippman: Work means different things to different people, and that depends on what your job is, how you feel about it, who your employer is. But I think that one trend that’s becoming true across the board, at least for professionals, is that we are working in America longer hours than almost anyone else in the world and than ever before in recent times. There’s a blurring of the lines between personal life and work. We’re never fully switched off. We’re on our cellphones; we’re checking our email every five minutes. There’s a joke about this new mantra that instead of work/life balance, come to me and talk about work/life integration. It’s something that works very well for employers and maybe less well for employees.

I’ve talked in the book about this whole idea of happiness in the workplace. It used to be that work was work and home was where you tried to find happiness and your social life and all the rest of it. There’s been a deliberate blurring of those boundaries. You see it where workplaces are offering dentists and doctors and video games and free food and that sort of thing to keep people working longer hours. [Employers are] even sending their staff to happiness training and mindfulness training.
Knowledge@Wharton: I have a 10-year-old and 7-year-old twins, and their school is doing

mindfulness training for kids. I’ve come around a little bit on it because I think it does help kids. Our kids are feeling more pressure at a younger age than they’ve ever felt before.

“Just by trying harder, we can’t actually control our own emotions and make ourselves happier in that way.”

Whippman: I think you’re absolutely right. Mindfulness has come to schools, to the military, to workplaces. It’s in corporations. It is a multibillion-dollar industry. I think mindfulness starts to feel like a tiny, teeny Band-Aid on a much, much bigger problem. You say your kids are under so much pressure, and I think that’s true of my kids and kids across the board and adults in the workplace. It’s this idea that we work these incredibly long hours, we’re very stressed and there’s pressure on us to be more productive than ever before. “Oh, and here’s your hour of mindfulness training every week.” It feels like you’re not really addressing the actual problem. You can’t pay your rent, you don’t have any health insurance, but oh, try a bit of mindfulness. You’re in a burning building and here’s a tiny little fire extinguisher. Try and sort it out.

The other thing about mindfulness is that there are great, grand claims for it. I am not saying that mindfulness is not helpful to certain people. It is. But the evidence for it is much weaker than is commonly claimed. There was a big meta-analysis [conducted] a year or two ago that showed there was no real difference in benefit between doing mindfulness and doing any kind of relaxation technique. Whatever that is for you, whether it’s getting a pedicure or just talking to a friend or listening to some music, mindfulness is of no benefit beyond that.

Knowledge@Wharton: Were there companies that you talked to that really showed that there was a level of happiness there? Or does pretty much every company have a level of angst in it?

Whippman: Some companies are better places to work than others, no doubt about it. I went to visit Zappos, which is very much pushing this happiness agenda. The CEO of the company, Tony Hsieh, is very interested in positive psychology. His company’s message is delivering happiness. You go to that company and there are balloon animals and parades and fireworks and they have out-of-hours socializing and free snacks. It’s very strongly encouraged that you socialize with your colleagues out of the workplace. I think this is a kind of corporate culture that is becoming more common. As I said before, this is blurring the lines between what is your boss’ business and your boss’ concern and what isn’t. For some people, that works great. Some people want to go to work and have a parade come past their desk and do a little disco and that kind of thing. For me, as a kind of awkward British person, I think it would be absolutely horrendous.

Knowledge@Wharton: Some companies make a Friday happy hour at the office the norm. A friend who worked for a big retail company told me they would have a once-a-month beer bash at the office. They were playing drinking games.

Whippman: That is particularly common around Silicon Valley and that kind of California culture. It’s this idea that your work mates should be your friends. They call it “cultural fit.” It’s the company culture, and you should take part in that. But I think it’s problematic for a lot of reasons. For me, I’m a mom, I work, I have young kids. I don’t want to be getting drunk in the office with my work mates. I want to be home. This pressure that the office has to be my social life, that I have to not just do my job and collect my paycheck, but I also have to emotionally perform and be a part of this whole big thing — I don’t want that. I think this socializing culture is particularly tough on women with families.

Knowledge@Wharton: This is something driven in part by millennials. Do you see it continuing for a long time, or will the next generation look at it differently?

Whippman: It’s hard to say because there could well be a backlash. People could say, “Just give me some space, I just want to go home. I don’t want to be doing my dry cleaning at work.” There [was an item] in the news recently that Facebook was actually paying for their female employees to have their eggs frozen so that they could delay child bearing. I feel like it’s getting to the point where it’s an intrusion on your personal liberty, your personal space and your private life. They’re not forcing anyone to do this, but it’s little by little.

Knowledge@Wharton: Some of these companies believe that these perks, like dry cleaning, are the way to go because you’re building culture within the corporation. There are people for whom that works perfectly.

“I think people are paradoxically likely to experience more happiness if they stop trying quite so hard.”

Whippman: The key element here should be choice. When you’re talking about making your company a good place to work that attracts good employees, there is nothing wrong with that. But I think cultural fit can quite often be a smoke screen for, “We only want a certain type of person to work at this company.” That can be problematic for diversity and for all kinds of reasons. Cultural fit means that you are kind of a big funster, that you drink with the boys every night. It could work very well for a 24-year-old software engineer who doesn’t have anywhere else to be, but it might not work so well for someone with a family or from a different kind of culture. It’s easy to say it has no bearing on your ability to do the job well.

Knowledge@Wharton: With all of this pursuit for happiness, a little less happiness ends up being a good thing from time to time?

Whippman: Well, not a little less happiness. But I think people are paradoxically likely to experience more happiness if they stop trying quite so hard. One of the things I noticed when we first moved here is that people talked about happiness almost like people talk about going on a diet. There’s no pleasure involved in it, but if I just try a bit harder, it would make me a good person or a better, more improved person to do this. I think to just take a step back, stop worrying about it, stop really pursuing it so relentlessly and just kind of hope that it comes along the way will actually lead to more happiness. There is quite a lot of research that backs that up, too.

Knowledge@Wharton: Are we setting ourselves up for another generation to follow in that path?
Whippman: This is a really big trend in parenting at the moment — that we are so invested in our kids’ happiness. When I was a kid, my mom [would say], “Off you go, go and play on your own, do your own thing,” and she wasn’t micromanaging my happiness. She wasn’t micromanaging every moment of my day, optimizing my experience.

With the coming of these helicopter parents who hover over our kids a lot, kids of college age now show more anxiety than any previous generation. There was one study recently that showed that an average high school or college student now has the same levels of anxiety as a psychiatric patient in the 1950s of a similar age. That’s grading it on the same test. So, I think we are creating a generation of anxious kids.

I think also for that generation, which has grown up with social media, happiness is really kind of the currency of social media. It’s all about putting your best foot forward and putting your blissful photos on Facebook where everybody is having a great time and everyone is at a great party and you’re Instagramming and it’s perfect. Everyone is talking about being authentic all the time, so obviously, it’s as authentic as nothing. I think that puts a great pressure on people now.

Social media is not one thing. There’s lots of different ways that people interact with social media. But one of the big things is making our lives seem as blissfully wonderful as they possibly can be. And it’s very easy; you just compare yourselves to others. I do it myself. We went apple picking in an orchard recently with my kids. Frankly, it was kind of a miserable day. It was really hot and our kids were whining the whole time. There was no water, there were no restrooms. But I still posted the one picture on my Facebook account of my kids smiling and holding up the apples and looking so happy. Everybody looking at that would think, what a perfect day they’ve had. And I do the same. I look at my neighbors or my friends and I say, “God, why is my life not like that?” It’s never been easier to compare ourselves unfavorably to other people.

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Monday, June 8, 2015

Mindfulness Can Literally Change Your Brain 06-08

Mindfulness Can Literally Change Your Brain



The business world is abuzz with mindfulness. But perhaps you haven’t heard that the hype is backed by hard science. Recent research provides strong evidence that practicing non-judgmental, present-moment awareness (a.k.a. mindfulness)changes the brain, and it does so in ways that anyone working in today’s complex business environment, and certainly every leader, should know about.
We contributed to this research in 2011 with a study on participants who completed an eight-week mindfulness program. We observed significant increases in the density of their gray matter. In the years since, other neuroscience laboratories from around the world have also investigated ways in which meditation, one key way to practice mindfulness, changes the brain. 
This year, a team of scientists from the University of British Columbia and the Chemnitz University of Technology were able to pool data from more than 20 studies to determine which areas of the brain are consistently affected. They identified at least eight different regions. Here we will focus on two that we believe to be of particular interest to business professionals.
The first is the anterior cingulate cortex (ACC), a structure located deep inside the forehead, behind the brain’s frontal lobe. The ACC is associated with self-regulation, meaning the ability to purposefully direct attention and behavior, suppress inappropriate knee-jerk responses, and switch strategies flexibly. People with damage to the ACC show impulsivity and unchecked aggression, and those with impaired connections between this and other brain regions perform poorly on tests of mental flexibility: they hold onto ineffective problem-solving strategies rather than adapting their behavior. 
Meditators, on the other hand, demonstrate superior performance on tests of self-regulation, resisting distractions and making correct answers more often than non-meditators. They also show more activity in the ACC than non-meditators. In addition to self-regulation, the ACC is associated with learning from past experience to support optimal decision-making. Scientists point out that the ACC may be particularly important in the face of uncertain and fast-changing conditions.
Source: Tang et al.
(Source: Tang et al.)
Source: Fox et al.
(Source: Fox et al.)
The second brain region we want to highlight is the hippocampus, a region that showed increased amounts of gray matter in the brains of our 2011 mindfulness program participants. This seahorse-shaped area is buried inside the temple on each side of the brain and is part of the limbic system, a set of inner structures associated with emotion and memory.
 It is covered in receptors for the stress hormone cortisol, and studies have shown that it can be damaged by chronic stress, contributing to a harmful spiral in the body. Indeed, people with stress-related disorders likedepresssion and PTSD tend to have a smaller hippocampus. All of this points to the importance of this brain area in resilience—another key skill in the current high-demand business world.
Hölzel et al.
(Source: Hölzel et al.)
These findings are just the beginning of the story. Neuroscientists have also shown that practicing mindfulness affects brain areas related to perception, body awareness, pain tolerance, emotion regulation, introspection, complex thinking, and sense of self. While more research is needed to document these changes over time and to understand underlying mechanisms, the converging evidence is compelling.
Mindfulness should no longer be considered a “nice-to-have” for executives. It’s a “must-have”:  a way to keep our brains healthy, to support self-regulation and effective decision-making capabilities, and to protect ourselves from toxic stress. It can be integrated into one’s religious or spiritual life, or practiced as a form of secular mental training.  When we take a seat, take a breath, and commit to being mindful, particularly when we gather with others who are doing the same, we have the potential to be changed.

Saturday, June 14, 2014

5 Things You Didn't Know About Stress 06-15

5 Things You Didn't Know About Stress

We all experience varying levels and lengths of stress, triggered by an array of scenarios – some logical, others not. Managing this powerful emotional and physiological response to adverse or demanding circumstances comes more naturally to some, but can certainly be taught to even the most nervous of them all. The first step to controlling stress is to know your own personal anxiety, down to its deepest core. What causes your stress? What alleviates it? What affect is it having on your mind and body and what can you do to stop it?
To assist you on your journey of stress-discovery, here are five truths about stress that you may not know – but definitely need to be made aware of.

1. Stress is contagious.

Anyone interacting with someone who’s stressed, especially for prolonged periods of time, has an increased risk of being affected by empathetic stress. Caregivers and family members of chronically stressed individuals are most at risk here, but even watching TV shows involving confrontations of stress can transmit the tension. This empathetic stress negatively impacts the immune system and is toxic to the mind and body in the long term. Know your limits when it comes to how much stress you can healthily expose yourself to. Also, be cognizant of how your worry may be negatively impacting those around you.
If you reach out to a sorrowful friend, a mourning parent, or a downhearted colleague who has suffered a sudden reversal of fortune or fate, be careful not to be overcome yourself by the apparent hardship. Remember to discriminate events themselves and your interpretations of them. It is not a demonstration of kindness or friendship to the people we care about to join them in surrendering to negative feelings. We do a better service to ourselves and others by remaining detached and avoiding unnecessary emotional reactions.
Still, if you are associated with someone who is depressed, stressed or hurt, show them kindness and give them a sympathetic ear; just don’t allow yourself to be pulled down.

2. Stress is detrimental to Sperm.

Stress can and will seep into every facet of your life if you let it, including the bedroom. Stressed men are found to have fewer, slower sperm, which can diminish fertility. While not conclusive yet as to how stress affects the quality of semen, it is possible that stress may trigger steroid hormones known to blunt levels of testosterone and sperm production.

3. Two stressed people equals less stress.

Seems counterintuitive, yes. But, when especially stressed, it is extremely helpful to share your feelings with someone who is having a similar anxious reaction to the same situation. Consider giving a presentation at work – perhaps nothing will ease your stress more than talking it out with a colleague who is undergoing the same scenario. Studies show that there is tremendous benefit gained by conversing with others whose emotional response is in line with your own.

4. Optimists are better at regulating stress.

A glass-half-full mentality may be the ticket to a more stress-free life. The “stress hormone” cortisol tends to be more stable for those with positive personalities. Pessimists have difficulty regulating their emotional and physical responses to particularly stressful situations.Optimists tend to be more solution-oriented and thus better react to the stress hormone – allowing it to amplify their get-up-and-go attitudes.

5. Not all stress is bad.

While stress is oftentimes the enemy, we can’t ignore its ability to push us to optimal alertness and performance. Short, but significant bouts of stress cause our brains to proliferate new nerve cells that improve mental performance. Stress hormones are an incredible adaptation that provide us with the ability to remember not only anxiety-ridden situations themselves, but more importantly, how will dealt with them – ingraining us with the power of resiliency, allowing us to be ready for whatever life may throw our way. Like most things in life, stress is only beneficial in small doses. Chronic stress leads to increased risk of chronic obesity, heart disease and depression.